Andrew Tyler, MD, PhD

• 06/2007-05/2015 MD University of Texas Southwestern Medical Center Dallas, TX

• 06/2007-05/2015 PhD University of Texas Southwestern Medical Center (Immunology) Dallas, TX

• 09/2005-06/2006MA Harvard University Cambridge, MA (Chemistry & Chemical Biology) Cambridge, MA

• 09/2002-06/2006BA Harvard University Cambridge, MA (Chemistry & Chemical Biology) Cambridge, MA

• 08/2020-07/2021Fellow in Orthopaedic Trauma Surgery
  Vanderbilt University Medical Center

• 07/2016-06/2020Resident in Orthopaedic Surgery
  Hospital of the University of Pennsylvania

• 06/2015-06/2016 Intern in Orthopaedic Surgery
  Hospital of the University of Pennsylvania

• TexasActive

• Tennessee Retired

• Pennsylvania Expired

• Pennsylvania Expired (training license)

• Delaware Expired (training license)

• ATLSActive

• ACLSActive

• BLSActive

• 2022 Physician of the Quarter
  HCA Houston Healthcare Clear Lake

• 2020 Emerging Leaders Program
  American Orthopaedic Association

• 2020 R. Bruce Heppenstall “Know-It-All” Award
  Department of Orthopaedic Surgery, University of Pennsylvania

• 2014Medical Student Inductee
  Alpha Omega Alpha Honors Society

• AOTrauma
• Orthopaedic Trauma Association
• American Orthopaedic Association
• American Academy of Orthopaedic Surgery
• Orthopaedic Research Society
• American Medical Association
• American Physician Scientists Association

• Orthopedic Surgery Liason, Trauma Committee, HCA Houston Healthcare Clear Lake, 2021-present

• Section editor, Spine, University of Pennsylvania Orthopaedic Journal, 2018-2019
• Section editor, Orthopaedic Oncology, University of Pennsylvania Orthopaedic Journal, 2016-2017
• Anatomy tutor, UT Southwestern Medical Center, 2009-2010
• Community Outreach manager, The Monday Clinic (a medical student-run free clinic for the local indigent population of Dallas, TX), UT Southwestern Medical Center, 2009-2010
• President, Harvard University Boxing Club, 2005-2006

• Co-PI (with Derek Donegan, MD), Foundation of Orthopaedic Trauma (FOT) Grant #6017-11: “Effect of Local Anesthetic on Fracture Healing in an Animal Model”
• PI, NINDS F31 Predoctoral Fellowship #5F31NS076081: “Immunotherapy Induced Regulation of Demyelinating Disease”
• Recipient fellow, T32 Institutional Training Grant #5T32AI005284: “Integrative Immunology Training Grant”
• Recipient fellow, T32 Institutional Training Grant #5T32GM008014: “Medical Scientist Training Program"

• 2022 Soft Tissue Course OTA Tampa, FL

• 2021 OTA Fellow’s Course OTA Virtual

• 2020 Advanced Case Controversies for Residents OTA Virtual

• 2020 SPDI Preparing for Practice SPDI Weehawken, NJ

• 2019 Trauma Advanced Principles AONA Glendale, AZ

• 2019 Trauma Resident Education Course Stryker Mahwah, NJ

• 2018 Surgical Approaches for Internal Fixation Smith & Nephew Memphis, TN

• 2017 Principles of Fracture Management AONA Chicago, IL

• 2017 Residents’ Knee & Hip BioSkills Event Zimmer Biomet Philadelphia, PA

• 2015-19 Surgical Approaches Workshop Johnson & Johnson West Chester, PA

• 2022 Orthopaedic Trauma Association Annual Meeting Tampa, FL

• 2022 Orthopaedic Trauma Association Annual Meeting Virtual

• 2020 Foundation for Orthopaedic Trauma Annual Meeting Las Vegas, NV

• 2018 Eastern Orthopaedic Association Annual Meeting Amelia Island, FL

• 2018 Orthopaedic Trauma Association Annual Meeting Orlando, FL

• 2011 American Association of Immunologists Annual Meeting San Francisco, CA

• 2010 Rare Neuroimmunologic Disorders Symposium Dallas, TX

• 2009-2013 UTSW Department of Pathology Annual Retreat Dallas, TX

• 2009-2013 UTSW Immunology Graduate Program Annual Retreat Dallas, TX

• 2007-2015 UTSW Medical Scientist Training Program Annual Retreat Dallas, TX

Peer-reviewed publications:

1. Steven NM, Tyler AF, Mitchell PM, Stinner DJ. “Preoperative and intraoperative considerations using intramedullary nails for the treatment of tibial shaft fractures below total knee arthroplasty.” J Orthop Trauma Nov 2022; 36(11): e437-41.
2. Tyler AF, Vincent C, Steven NM, Payton H, Boyce RH, Collinge CA, Mitchell PM. “Hands-free femoral traction using the Bookwalter retractor system during anterior approaches to the acetabulum.” J Orthop Trauma 1 Aug 2022 epublished ahead-of-print.
3. Steven NM, Tyler AF, Boyce RH, Mitchell PM. “Extra-articular unstable iliac fractures: Associated injuries, fixation strategies, and outcomes.” J Orthop Trauma Jul 2022; 36(7): 339-42.
4. Tyler AF, Ahn J, Donegan DJ. “Local infiltrative analgesia of murine femur fractures in vivo does not inhibit fracture healing.” Cureus 14(3): e23569.
5. Tyler AF, Rose T, Day S, Kenia J, Horan AD, Mehta S, Donegan DJ. “Comparison of spatiotemporal gait parameters in patients following operative treatment of trimalleolar ankle fractures at six months versus healthy controls.” Foot & Ankle Orthopaedics 30 Jun 2020; 5(3): 1-7.
6. Tyler AF, Mendoza JP, Firan M, Karandikar NJ. “CD8+ T cells are required for glatiramer acetate therapy in autoimmune demyelinating disease.” PLoS One 21 Jun 2013; 8(6): e66772.
7. Ortega SB, Kashi VP, Tyler AF, Cunnusamy K, Mendoza JP, Karandikar NJ. “The disease-ameliorating function of autoregulatory CD8+ T cells is mediated by the targeting of encephalitogenic CD4+ T cells in experimental autoimmune encephalomyelitis.” J Immunol 1 Jul 2013; 191(1): 117-26.
8. York NR, Mendoza JP, Ortega SB, Benagh A, Tyler AF, Firan M, Karandikar NJ. “Immune regulatory CNS- reactive CD8+ T cells in experimental autoimmune encephalomyelitis.” J Autoimmun Aug 2010; 35(1): 33-44.
9. Fleisig HB, Orazio NI, Liang H, Tyler AF, Adams HP, Weitzman MD, Nagarajan L. “Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA- binding protein 2 into aggresomes.” Oncogene 19 Jul 2007; 26(33): 4797-805.
10. Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL. “Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.” J Am Chem Soc 7 Mar 2007; 129(9): 2456-7.

Non-peer-reviewed publications:

1. Tyler A Lopas L, Ahn J. “Bone, Cartilage, and Tendon Healing.” Rockwood & Green On-Call 2020.
2. Tyler A, Arlet V. “Tips & Tricks: Increasing Sacropelvic Fixation with the “Four Rods” Technique in Parkinson’s-Related Camptocormia.” UPOJ June 2019; Vol 29: 89-91.
3. Tyler A Weber K. “Tips & Tricks: Prophylactic Femoral Nailing for Metastatic Carcinoma.” UPOJ June 2017; Vol 27: 113-4.

Review articles:

1. Mehta S, Tyler A, Hast M. “Understanding the Basics of Computational Models in Orthopaedics: A Nonnumeric Review for Surgeons.” JAAOS Oct 2017; 25(10): 684-92.

Book chapters:

1. Tyler A, Kelly AM, Ott N, Kelly MP, Miller L, Kelly JD. “Arthroscopic Cuff Repair – Set Up and Fundamentals”. Premier Approaches to Arthroscopic Rotator Cuff Repair. 2020, SLACK Incorporated.
2. Lopas L, Tyler A, Mehta S. “Extracapsular Hip Fractures”. Evidence Based Orthopaedics, 2nd edition. 2021, Wiley-Blackwell.
3. Tsai C, Tyler A, Baldwin K. “Orthopedic Devices”. Emergency Management of the High-Tech Patient in Acute and Critical Care. 1st edition. 2021, Wiley-Blackwell.

Abstracts:

1. Tyler A, Ahn J, Donegan D. “Local infiltrative analgesia of murine femur fractures in vivo does not inhibit fracture healing.” Orthopaedic Trauma Association Annual Meeting Oct 2020
2. Tyler A, Sloan M, Sheth N, Donegan D. “General anesthesia increases complications following hip fracture surgery.” Eastern Orthopaedic Association Annual Meeting Oct 2018.
3. Tsai C, Tyler A, Baldwin K. “Orthopedic Devices”. Emergency Management of the High-Tech Patient in Acute and Critical Care. 1st edition. 2021, Wiley-Blackwell.
4. Kashi V, Ortega S, Tyler A, Karandikar N. “Modulation of dendritic cell function by neuroantigen- specific CD8 + T cells.” J Immunol May 2013; 190: 127.4.
5. Ortega S, Kashi V, Tyler A, Mendoza J, Cunnusamy K, Karandikar N. “Autoregulatory CD8+ T cells modulate CNS autoimmunity by targeting encephalitogenic CD4 T cells.” J Immunol May 2013; 190: 191.11.
6. Ortega S, Tyler A, Kashi V, Mendoza J, Benagh A, Karandikar, N. “Treatment of autoimmune demyelination by autoregulatory CD8+ T-cells.” J Immunol Apr 2011; 186: 115.24.
7. Tyler A, Mendoza J, Ortega S, Firan M, Karandikar N. “CD8+ T-cells are required for the action of glatiramer acetate therapy for autoimmune demyelinating disease.” J Immunol Apr 2011; 186: 164.19.
8. Bernal F, Walensky LD, Tyler AF, Korsmeyer SJ, Verdine GL. “Selective targeting of the p53-hDM2 interaction using hydrocarbon-stapled p53 peptides.” Blood Nov 2006; 108(11); 159A-159A.

Other publications:

1. Tyler A, CD8+ T Cells Are Required for the Therapeutic Action of Glatiramer Acetate in Autoimmune Demyelinating Disease. Doctoral Thesis, UT Southwestern Electronic Theses and Dissertations, March 2013.

Research presentations:

1. Tyler A, Ahn J, Donegan D. (2020). “Local infiltrative analgesia of murine femur fractures in vivo does not inhibit fracture healing.” Presented at: Orthopaedic Trauma Association Annual Meeting, Virtual.
2. Tyler A, Ahn J, Donegan D. (2020). “The effect of local anesthetic on fracture healing in an animal model.” Presented at: Foundation for Orthopaedic Trauma Annual Meeting, Las Vegas, NV.
3. Tyler A, Ahn J, Donegan D. (2019). “The effect of local anesthetic on fracture healing in an animal model.” Presented at: Research Day, University of Pennsylvania, Philadelphia, PA.
4. Tyler A, Sloan M, Sheth N, Donegan D. (2018). “General anesthesia increases complications following hip fracture surgery.” Presented at: Rapid Fire Session 4E – Hip Arthroscopy/Hip Fractures, Eastern Orthopaedic Assocation Annual Meeting, Amelia Island, FL.
5. Tyler A, “CD8+ T Cells Are Required for the Therapeutic Action of Glatiramer Acetate in Autoimmune Demyelinating Disease.” Thesis Defense presented at: University of Texas Southwestern Medical Center, Dallas, TX.
6. Tyler A, Mendoza J, Ortega S, Firan M, Karandikar N. (2011). “CD8+ T-cells are required for the action of glatiramer acetate therapy for autoimmune demyelinating disease.” Presented at: American Association for Immunologists Annual Meeting; San Francisco, CA.
7. Tyler A, Mendoza J, Ortega S, Firan M, Karandikar N. (2011). “CD8+ T-cells are required for the action of glatiramer acetate therapy for autoimmune demyelinating disease.” Presented at: UT Southwestern Medical Center Department of Immunology Annual Retreat; Dallas, TX.

Poster presentations:

1. Moreno AF, Obudzinski S, Taylor PR, Tyler AF, Chen A, Obremskey WT, Southeastern Fracture Consortium. (2022). “Management of femur and tibia shaft fractures in chronic spinal cord injury patients.” Presented at: Orthopaedic Trauma Association Annual Meeting; Tampa, FL.
2. Tyler A, Ahn J, Donegan D. (2020). “Direct infiltration of femur fractures with local anesthetic does not reduce callus formation in an animal model.” ePoster presented at: American Academy of Orthopaedic Surgeons Annual Meeting.
3. Kashi V, Ortega, S, Tyler A, Karandikar N. (2013). “Modulation of dendritic cell function by neuroantigen-specific CD8+ T cells.” Presented at: American Association for Immunologists Annual Meeting; Honolulu, HI.
4. Ortega S, Kashi V, Tyler A, Mendoza J, Cunnusamy K, Karandikar N. (2013). “Autoregulatory CD8+ T cells modulate CNS autoimmunity by targeting encephalitogenic CD4+ T cells.” Presented at: American Association for Immunologists Annual Meeting; Honolulu, HI.
5. Ortega S, Tyler A, Kashi V, Mendoza J, Benagh A, Karandikar N. (2011). “Treatment of autoimmune demyelination by autoregulatory CD8+ T-cells.” Presented at: American Association for Immunologists Annual Meeting; San Francisco, CA.
6. Tyler A, Mendoza J, Ortega S, Firan M, Karandikar N. (2011). “CD8+ T-cells are required for the action of glatiramer acetate therapy for autoimmune demyelinating disease.” Presented at: UT Southwestern Medical Center Department of Immunology Annual Retreat; Dallas, TX.
7. Tyler A, Mendoza J, Ortega S, Firan M, Karandikar N. (2011). “CD8+ T-cells are required for the action of glatiramer acetate therapy for autoimmune demyelinating disease.” Presented at: American Association for Immunologists Annual Meeting; San Francisco, CA.

Lectures:

1. Tyler A. (2021). “Acetabular fractures.” Presented at: Orthopaedic Surgery Resident Conference, Vanderbilt University, Nashville, PA.
2. Tyler A. (2020). “Ballistic trauma for the orthopaedic surgeon.” Presented at: Orthopaedic Surgery Resident Conference, University of Pennsylvania, Philadelphia, PA
3. Tyler A. (2019). “Geriatric Fragility Fractures.” Presented at: Orthopaedic Surgery Grand Rounds, University of Pennsylvania, Philadelphia, PA.
4. Tyler A. (2018). “The SPRINT Trial.” Presented at: Orthopaedic Surgery Grand Rounds, University of Pennsylvania, Philadelphia, PA.
5. Tyler A. (2017). “Delayed Union, Malunion, and Nonunion.” Presented at: Orthopaedic Surgery Grand Rounds, University of Pennsylvania, Philadelphia, PA.
6. Tyler A. “Supracondylar Humerus Fractures: Past and Present.” Presented at: Orthopaedic Surgery Grand Rounds, University of Pennsylvania, Philadelphia, PA.